ea0022p23 | Adrenal | ECE2010
Reuss Miriam
, Kroiss Matthias
, Johanssen Sarah
, Beyer Melanie
, Zink Martina
, Hartmann Michaela
, Dhir Vivek
, Wudy Stefan
, Arlt Wiebke
, Sbiera Silviu
, Allolio Bruno
, Fassnacht Martin
Background: The multi-tyrosine kinase inhibitor sunitinib is approved for advanced renal cell carcinoma and gastrointestinal stroma tumors. It targets both tumor vessels and malignant cells. Animal experiments have pointed to a direct adrenotoxic effect of the drug.Aims: We hypothesized that sunitinib may inhibit proliferation of adrenocortical cancer (ACC) cells and influence adrenal steroid hormone synthesis.Results: Sunitinib re...